Evaluation of the INSPIRE trial and its implications for lung transplantation with normothermic portable ex vivo lung perfusion

Normothermic ex vivo allograft blood perfusion in clinical heart transplantation.

BACKGROUND Cold ischemia associated with cold static storage is an independent risk factor for primary allograft failure and survival of patients after orthotopic heart transplantation. The effects of normothermic ex vivo allograft blood perfusion on outcomes after orthotopic heart transplantation compared to cold static storage have been studied. METHODS In this prospective, nonrandomized, s...

Reconditioning of lungs donated after circulatory death with normothermic ex vivo lung perfusion.

BACKGROUND The use of donation-after-circulatory-death (DCD) donors for lung transplantation has come into practice. In this study we investigated whether DCD lungs can be resuscitated after warm ischemia with normothermic ex vivo lung perfusion (EVLP). METHODS Four hours after cardiac arrest, beagle dogs were divided into two groups (n = 6 each): those with static cold storage (SCS group) an...

New perspectives in lung transplantation: from conventional preservation to ex vivo lung perfusion and lung reconditioning.

Feasibility of Lung Transplantation From Donation After Circulatory Death Donors Following Portable Ex Vivo Lung Perfusion: A Pilot Study.

BACKGROUND Donation after circulatory death (DCD) has the potential to significantly alleviate the shortage of transplantable lungs. We report our initial experience with the use of portable ex vivo lung perfusion (EVLP) with the Organ Care System Lung device for evaluation of DCD lungs. METHODS We performed a retrospective review of the DCD lung transplantation (LTx) experience at a single i...

Ex vivo lung perfusion in clinical lung transplantation--state of the art.

Ex vivo lung perfusion (EVLP) has emerged as a new technique for assessing and potentially reconditioning human donor lungs previously unacceptable for clinical transplantation with the potential to dramatically push the limits of organ acceptability. With the recent introduction of portable EVLP, a new era in lung preservation may be upon us with the opportunity to also limit organ ischaemic t...